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Unfortunately, targeted treatments inside clinical trials have had limited success up to now, partially because of the heterogeneity and you may plasticity out of GBM plus because of practical limits(193)
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Considering the genomic complexity and you will several signaling routes from GBM, good monotherapy cannot to be effective. For this reason, to be successful, novel GBM therapies target collection of physical pathways and can include novel strategies such as electric occupation, viral, otherwise cellphone-built therapeutic tips.